UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby. After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. Using the Red Key near it will spawn a red room, This room will randomly choose from many types, including (but not limited to) any regular room from that floor, treasure rooms, curse rooms, devil rooms, angel rooms, I AM ERROR rooms and more, In rooms with multiple door outlines, the closest one will be opened, Attempting to create a room outside the maximum boundary (13 x 13 rooms) of the map will take you to an I AM ERROR room. If it does, it will drop a random trinket, coin, heart and key, The Walnut trinket is destroyed once the effect activates, Causes any orbitals you have to stop moving while held, Stops shooting familiars from moving (including Lilith's Incubus), Some familiars with irregular movement are not affected by Duct Tape, such as Abel, BBF, Bumbo, Guppy's Hair Ball, Lil Gurdy, Punching Bag, Robo-Baby 2.0, Succubus, *, grey, gray, tp, toilet, paper, roll, silver, While held, shops will now appear on the womb floors (The Womb, Utero and Scarred Womb), UNLOCK: Unlock this item by defeating Delirium in The Void floor with Cain, While held, item rooms now appear on the womb floors (The Womb, Utero and Scarred Womb), REPENTANCE - Causes item rooms to appear on Corpse floors, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Samson, While held, restock boxes will always spawn in item rooms, *, cent, money, cash, coin, pixel, blue, green, p2w, Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies, dealing double tear damage for the impact of the Locust and 60 damage for the explosion, Can be dangerous as the fly will target the nearest enemy, which can be close enough to catch Isaac in its blast radius, UNLOCK: Unlock this trinket by defeating Isaac in the Cathedral as Apollyon, At the start of each new hostile room you spawn a green attack fly, which will target a nearby enemy, deal double your tear damage and then poison them, UNLOCK: Unlock this item by beating Satan with Apollyon, At the start of each new hostile room you spawn a yellow attack fly, which will target a nearby enemy, deal double your tear damage and apply a slowing effect to it, UNLOCK: Unlock this trinket by defeating ??? *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. It also no longer prevents damage from self-harming mechanics e.g. Increases the maximum heart limit to 18. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. Abel, UNLOCK: Unlock this trinket by defeating Isaac, ?? Bethany - Activating an item using soul charges is sometimes free, Jacob & Esau - The character who picks up Birthright gains copies of three of the other character's passive items, UNLOCK: Unlock this item by defeating ??? gray, horns, Tears are replaced with a knife which can be charged and thrown in a boomerang style action, The knife can also do damage without being thrown as a close range melee weapon, When used as a melee weapon, Mom's Knife deals your tear damage * 2 per tick, At the furthest point from Isaac the knife deals your tear damage * 6, UNLOCK: Unlock this item by beating Satan with Isaac, Item Pool: Item Room, Devil Room, Challenge Room, Mom's Chest, * dungeon room, blood challenge room, arena pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, grey, gray, silver, Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. you can wish list it on steam here > mewgenics.com more info dropping on Halloween! REPENTANCE - Skatole now prevents damage from eternal flies and Hush flies. 132. - Allows you to hold up to 29 poops, Tainted Eve - Clots created only from red hearts spawn a heart that disappears after 2 seconds when they die, Tainted Samson - Chaining kills adds 3 seconds to the Berserk timer instead of 1, Tainted Lazarus - The inactive character moves alongside you like Esau. 531. red, drip, Isaac's health is set to 1 and he also gains 9 extra lives, Each time Isaac dies, he will respawn with 1 Health, Has a chance to drop from the Super Pride mini boss, The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost), Counts as 1 of 3 cat items needed towards the Guppy transformation, Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Gives Isaac demon wings and the ability to fly. Item Synergies - Isaac Cheat Sheet - Platinum God pink, red, eye, glow moms contacts mom contact, Upon use, this item causes Isaac to fart and poison any enemies in close proximity, The Bean deals 5 damage, then poisons enemies for 6 total ticks of damage, The poison deals your current tear damage per tick, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, team bean, #teambean, brown, kidney, An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals, UNLOCK: Unlock this item by beating Satan with Maggy, * angel room pool, god room pool, angel room item, baby, wings, A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range, UNLOCK: Unlock this item by beating the Dark Room with Azazel, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, black, grey, This item will modify drops from room clearing and champion enemies based on your current player state. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, white, red, pink, When used, slows down all enemies in the current room and their projectiles for about 8 seconds, * item room, treasure room, item room pool, hour glass, hourglass, egg timer, sandbrown, glass, A familiar which follows Isaac around and shoots blood tears that deal 5 damage, The tears appear red but have no additional damage, Sister Maggy fires tears at a rate of 1 tear per second, REPENTANCE - Sister Maggy's tear damage has been increased to 5 (from 3.5), to match its original Flash damage, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red, dead, baby, Isaac's tears are replaced with a laser that has unlimited range and can only fire at right angles, Lasers travel through enemies but not obstacles in the room, Synergizes with most items that affect how many tears you fire (20/20, Mutant Spider etc.) Binding of Isaac Item Rank & Item Pool Quality Spreasheet for MEGA If the heart is hit, Isaac will take damage, Most enemies will target the heart over Isaac himself, Blood donation machines and devil beggars can be used for free. See the dedicated Devil room page for more details, Reveals the entire map and shows the icons for every room which has one, This is completely useless if you currently have both the Treasure Map and The Compass, Doubles your current red hearts up to full health, * , the lost item pool, playing, card, white, red, When used, turns all pickups, chests and non-boss enemies in the room into Bombs, UNLOCK: Unlock this item by getting a 3 win streak, When used, turns all pickups, chests and non-boss enemies in the room into Coins, UNLOCK: Unlock this item by defeating The Lamb in under 20 minutes, When used, turns all pickups, chests and non-boss enemies in the room into Keys, UNLOCK: Unlock this item by defeating The Lamb without taking hearts, coins and bombs, When used, turns all pickups, chests and non-boss enemies in the room into Hearts, UNLOCK: Unlock this item by defeating any floor after Basement I with only half a heart of health (works as The Lost), Teleports you to the Devil Deal Room on the current floor, When used, instantly kills you and spawns 10 pickup on the floor, Each of the 10 things spawned can be any type of consumable or sometimes a pedestal item (up to a maximum of 3 pedestal items), Any pedestal item created by Suicide King will be related to the room where it was used, meaning that using it in the Angel room will spawn Angel room items, UNLOCK: Unlock this card by beating Challenge #7 (Suicide King), UNLOCK: Unlock this card by defeating Mega Satan as Tainted Magdalene, A card which can be thrown as a projectile directly infront of Isaac, instantly killing anything it hits, including most bosses, If thrown at a multi-phase boss with multiple forms such Satan, Mega Satan or Hush it will only kill that particular phase of the boss, If thrown at a multi-phase boss that works from a single health bar such as Isaac, ???
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